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A morphine injection is an opioid medication that treats severe pain. It blocks pain signals in your brain to relieve symptoms. A healthcare provider will inject this medication underneath your skin in a hospital or clinic setting. The usual initial adult dose of MSIR for patients who have not previously received opioid analgesics is 5 or 10 mg, orally, every 4 hours. Rybelsus Find patient medical information for Morphine Sulfate IR oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. hourly may be needed if symptoms are severe or in the last days of life]. Lower doses, e.g. 1.25 – 2.5mg may be required in the opioid-sensitive, elderly or 15 mg oxycodone/30 mg morphine = 120 mg oxycodone/x mg morphine x Taper ROT (Morphine IR 15 mg BID). Speed of reduction will vary by indication